Common Drug Name
Milbemycin oxime plus spinosad
What should I discuss with my veterinarian while considering Trifexis?
Talk to your veterinarian about the heartworm testing that is recommended before starting your pet on a heartworm prevention program.
Some intestinal parasites, such as hookworms and roundworms can be spread to people. Talk to your veterinarian about other measures you can take to prevent your pet from being infected with intestinal worms, and protecting yourself.
Notify your veterinarian of any other medications or supplements your pet is taking, and also if your pet has had any reactions to previous medications.
What should I do if I miss a dose?
If a dose is missed, give the tablet immediately and resume giving a tablet every 30 days (once a month). Contact your veterinarian regarding the need to have your pet heartworm tested in 6-7 months.
If vomiting occurs within one hour of administration, redose with another full dose.
What is the most important information I should know?
If the interval between doses is longer than one month, or the dog is not treated for at least three months after the end of the mosquito season, the efficacy of the drug is reduced.
Who should not take it?
Not for use in dogs who are hypersensitive (allergic) to it.
Consult your veterinarian regarding heartworm testing your dog prior to and during use of this medication.
Use with caution in dogs with pre-existing epilepsy.
Not for use in Collies or other herding breeds over the recommended heartworm prevention dose unless under the strict supervision of a veterinarian. If your dog is one of these breeds and received a higher dose, observe your pet for at least 8 hours after giving the medication for weakness, staggering, fever, dilated pupils, trembling, or pressing the head against a wall. Contact your veterinarian immediately if you see these signs.
Do not use in puppies less than 8 weeks of age or less than 5 pounds.
Use with caution in breeding females. The safe use of milbemycin oxime plus spinosad in breeding males has not been evaluated.
Consult your veterinarian regarding physical examinations and heartworm testing your pet prior to, and during, treatment with Trifexis.
Properly dispose of unused medication, as it may be toxic to fish and other animals.
What side effects may be seen when taking TriFexis?
Side effects are rare at the recommended dosage. May see vomiting, decreased activity, decreased appetite, diarrhea, itching and reddening of the skin. If you observe any of these signs, contact your veterinarian. Puppies less than 14 weeks of age may experience a higher rate of vomiting.
Since the introduction of Trifexis, additional side effects reported are trembling/shaking, ataxia, seizures, and hypersalivation.
If your pet experiences an allergic reaction to the medication or the dying of parasites, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.
How is it stored?
Store in a tight, light-resistant, childproof container at room temperature. Keep out of reach of children and pets.
What should I do if I know of or suspect there has been an overdose?
In an overdose you may see vomiting, tremors, decreased activity, salivation, coughing and vocalization.
If you know or suspect your pet has had an overdose, or if you observe any unusual signs, symptoms, or behaviors, contact your veterinarian immediately.
What should I avoid when giving my pet Trifexis?
Notify your veterinarian of any other medications, including vitamins and supplements, your pet is taking while your pet is receiving Trifexis.
Serious adverse reactions have been reported following the simultaneous use of spinosad and ivermectin at doses higher than the heartworm prevention dose.
No known food interactions.
Where is more information available?
Ask your veterinarian, consult with one of our pharmacists at 1-800-447-3021, or see the
Patient Information Sheet on this medication.